Adcetris(brentuximab vedotin)
Adcetris (brentuximab vedotin) is an antibody drug conjugate pharmaceutical. Brentuximab vedotin was first approved as Adcetris on 2011-08-19. It is used to treat hodgkin disease and large-cell lymphoma immunoblastic in the USA. It has been approved in Europe to treat hodgkin disease and non-hodgkin lymphoma. The pharmaceutical is active against tumor necrosis factor receptor superfamily member 8.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Adcetris
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| adcetris | Biologic Licensing Application | 2025-11-11 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hodgkin disease | — | D006689 | C81 |
| large-cell lymphoma immunoblastic | — | D016400 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
brentuximab vedotin, Adcetris, Seagen Inc. | |||
| 2029-11-10 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9042 | Injection, brentuximab vedotin, 1 mg |
Clinical
Clinical Trials
206 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hodgkin disease | D006689 | — | C81 | 11 | 19 | 4 | — | 3 | 32 |
| Lymphoma | D008223 | — | C85.9 | 7 | 16 | 3 | — | 3 | 28 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 7 | 6 | 1 | — | 1 | 13 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 6 | 6 | 1 | — | 1 | 12 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 3 | 6 | 2 | — | 1 | 12 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 4 | 4 | 1 | — | 1 | 8 |
| T-cell lymphoma | D016399 | — | — | 2 | 5 | 1 | — | — | 7 |
| Mycosis fungoides | D009182 | — | C84.0 | 3 | 4 | 1 | — | — | 7 |
| Primary cutaneous anaplastic large cell lymphoma | D054446 | — | C86.6 | — | 2 | 1 | — | — | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 3 | 5 | — | — | — | 7 |
| T-cell lymphoma peripheral | D016411 | — | — | 2 | 4 | — | — | 1 | 6 |
| B-cell lymphoma | D016393 | — | — | 2 | 6 | — | — | — | 6 |
| Neoplasms | D009369 | — | C80 | 2 | 3 | — | — | — | 5 |
| Follicular lymphoma | D008224 | — | C82 | 1 | 4 | — | — | — | 4 |
| Sezary syndrome | D012751 | — | C84.1 | 2 | 3 | — | — | — | 4 |
| Lymphomatoid papulosis | D017731 | — | C86.6 | — | 3 | — | — | — | 3 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 2 | — | — | — | 3 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 2 | 2 | — | — | — | 3 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | 1 | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Graft vs host disease | D006086 | — | D89.81 | 2 | — | — | — | — | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | — | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
| Uterine cervical neoplasms | D002583 | — | — | 1 | — | — | — | — | 1 |
| Cutaneous malignant melanoma | D000096142 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Brentuximab vedotin |
| INN | brentuximab vedotin |
| Description | Brentuximab Vedotin (chimeric mab) |
| Classification | Antibody |
| Drug class | synthetic analogs of the dolastatin series; monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1742994 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB08870 |
| UNII ID | 7XL5ISS668 (ChemIDplus, GSRS) |
Target
Agency Approved
TNFRSF8
TNFRSF8
Organism
Homo sapiens
Gene name
TNFRSF8
Gene synonyms
CD30, D1S166E
NCBI Gene ID
Protein name
tumor necrosis factor receptor superfamily member 8
Protein synonyms
CD30, CD30L receptor, cytokine receptor CD30, Ki-1 antigen, Lymphocyte activation antigen CD30
Uniprot ID
Mouse ortholog
Tnfrsf8 (21941)
tumor necrosis factor receptor superfamily member 8 (Q60846)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,964 documents
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Safety
Black-box Warning
Black-box warning for: Adcetris
Adverse Events
Top Adverse Reactions
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11,092 adverse events reported
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