Adcetris(brentuximab vedotin)
Adcetris (brentuximab vedotin) is an antibody drug conjugate pharmaceutical. Brentuximab vedotin was first approved as Adcetris on 2011-08-19. It is used to treat hodgkin disease and large-cell lymphoma immunoblastic in the USA. It has been approved in Europe to treat hodgkin disease and non-hodgkin lymphoma. The pharmaceutical is active against tumor necrosis factor receptor superfamily member 8.
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
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Start date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Adcetris
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| adcetris | Biologic Licensing Application | 2025-02-19 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hodgkin disease | — | D006689 | C81 |
| large-cell lymphoma immunoblastic | — | D016400 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
brentuximab vedotin, Adcetris, Seagen Inc. | |||
| 2029-11-10 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9042 | Injection, brentuximab vedotin, 1 mg |
Clinical
Clinical Trials
197 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 4 | 7 | 3 | 3 | 9 | 23 |
| Hodgkin disease | D006689 | — | C81 | 3 | 3 | 2 | 1 | 8 | 15 |
| T-cell lymphoma | D016399 | — | — | 2 | 4 | — | 1 | 3 | 9 |
| T-cell lymphoma peripheral | D016411 | — | — | 2 | 4 | — | 1 | 2 | 8 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 1 | 1 | — | 1 | 1 | 4 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | — | — | — | 1 | 2 | 3 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | — | 1 | — | — | 1 |
| B-cell lymphoma | D016393 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Extranodal nk-t-cell lymphoma | D054391 | — | C86.0 | 1 | 1 | — | — | — | 1 |
| Enteropathy-associated t-cell lymphoma | D058527 | — | C86.2 | — | 1 | — | — | — | 1 |
| Intestinal diseases | D007410 | — | K63.9 | — | 1 | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Brentuximab vedotin |
| INN | brentuximab vedotin |
| Description | Brentuximab Vedotin (chimeric mab) |
| Classification | Antibody |
| Drug class | synthetic analogs of the dolastatin series; monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1742994 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB08870 |
| UNII ID | 7XL5ISS668 (ChemIDplus, GSRS) |
Target
Agency Approved
TNFRSF8
TNFRSF8
Organism
Homo sapiens
Gene name
TNFRSF8
Gene synonyms
CD30, D1S166E
NCBI Gene ID
Protein name
tumor necrosis factor receptor superfamily member 8
Protein synonyms
CD30, CD30L receptor, cytokine receptor CD30, Ki-1 antigen, Lymphocyte activation antigen CD30
Uniprot ID
Mouse ortholog
Tnfrsf8 (21941)
tumor necrosis factor receptor superfamily member 8 (Q60846)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,215 documents
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Safety
Black-box Warning
Black-box warning for: Adcetris
Adverse Events
Top Adverse Reactions
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10,166 adverse events reported
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